histone H3K4 trimethyltransferase activity [GO_0140999]

Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3.
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Open histone H3K4 trimethyltransferase activity in VFB

Term Information

  • ID: GO_0140999
  • Name: histone H3K4 trimethyltransferase activity
  • Definition: Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3.
  • Synonyms:
  • Type:
  • Comment:

VFB Term Json

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            "Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3."
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            "short_form": "GO_0042800",
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            "label": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter"
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