immature lobula columnar neuron LC14 [FBbt_00052343]

immature lobula columnar neuron LC14

ID: FBbt_00052343

Immature form of a lobula columnar 14 (dorsal cluster) neuron (Hassan et al., 2000; Zheng et al., 2006). It is born in the early larva and extends a neurite to the contralateral hemisphere during the larval stage, but does not enter the developing optic lobe until the late larval stage (Hassan et al., 2000; Zheng et al., 2006; Langen et al., 2013). Initially, all the contralateral axons extend into the medulla, but most retract back to the lobula prior to eclosion, leaving around one third of these neurons innervating the medulla (Langen et al., 2013). There are approximately 22-68 of these cells per hemisphere, with no correlation between the number of medulla-targeting cells and total number, or the number of cells in each hemisphere in the same organism (Langen et al., 2013; Linneweber et al., 2020).

Final lobula/medulla target choice based on Notch signalling during the pupal stage, but not specified at birth (Langen et al., 2013).